Key factors in antibiotic resistance

Commensal Flora May Play Key Role in Spreading Antibiotic Resistance

A ntibiotic resistance among commensal bacteria represents a major avenue for the development of resistance in bacterial pathogens. Although the concept that commensal flora play a major role in disseminating bacterial resistance was developed at least 30 years ago, it was set aside for several reasons. First, the more immediate threat to humans from resistant bacteria is due to pathogens, not ...

Mechanisms of antibiotic resistance determined by resistance-transfer factors.

Unowsky, Joel (Northwestern University Medical School, Chicago, Ill.), and Martin Rachmeler. Mechanisms of antibiotic resistance determined by resistance-transfer factors. J. Bacteriol. 92:358-365. 1966.-This study was concerned with the mechanism of expression of drug resistance carried by resistance-transfer (R) factors of two types: fi(-) (negative fertility inhibition) and fi(+) (positive f...

Bacterial SOS May Be the Key to Combating Antibiotic Resistance

Antibiotic overuse: a key driver of antimicrobial resistance.

Factors involved in beta-lactam antibiotic resistance in Pseudomonas aeruginosa.

A temperature-sensitive mutant, strain SS, which is assumed to be devoid of beta-lactamase activity and deficient in a permeability barrier to antibiotics, was isolated from a beta-lactamase-less mutant, strain L-2, derived from Pseudomonas aeruginosa IFO 3080. By comparing the beta-lactam antibiotic susceptibility between strains IFO 3080, L-2, and SS, the involvement of both beta-lactamase an...